[Changes in the vascular wall and ischemic damages to the myocardium in reversible episodes of heart muscle ischemia]. / Izmeneniia sosudistoi stenki i ishemicheskie povrezhdeniia miokarda pri obratimykh épizodakh ishemii serdechnoi myshtsy.

When no anaesthetic is used, even 3-5 short-term disturbances of the myocardium supply with blood (during a few days) are enough for its initial necrosis and for damage of its vascular bed. In acute experiments on rats rutin discovers the ability to resist such damages, but on the chronic model of stenocardia in dogs its therapeutic effect can be found only under conditions of limitation of the ischemic effect by purposefully chosen complex medicinal therapy.

[Effect of small doses of pituitrin on electrocardiography of ischemia in the experiment]. / Vliianie malykh doz pituitrina na ishemicheskie sdvigi élektrokardiogrammy v éksperimente.

A new type of reaction to the myocardial ischemia was established in chronic experiments in conscious dogs. It consists in some changes of local myocardial activity and, consequently, in constant or transient normalization of ECG. Pharmacological stabilization of this process augments myocardial resistance to ischemia 40-50 times and more. The role of small doses of pituitrin in this reaction was established.

[The sequelae of transient myocardial ischemia in chronic experiments]. / Izuchenie posledstvii vremennoi ishemii miokarda v khronicheskikh opytakh.

Reversible short-term and local myocardial ischemia in non-anaesthetized dogs involved a functional (if changing the activity of CPK) and morphologic aftereffect. At the same time it is possible to find some mechanisms of compensation (in chronic experiment).

[Myocardial necrosis in chronic course of ischemic heart disease]. / Nekrozy v miokarde pri khronicheskom techenii ishemicheskoi bolezni serdtsa.

The possibility of myocardial necrosis occurrence in coronary failure proceeding as atypical myocardial infarction was examined in 176 patients with chronic types of coronary heart disease and in experiments with 16 dogs with reversible coronary failure simulated in chronic tests. 99mTe-labeled pyrophosphate myocardial scintigraphy was used in the clinical studies. Myocardial pyrophosphate accumulation was recorded in 37% of patients with angina pectoris without a history of myocardial infarction and 73% myocardial infarction survivals. Histological evidence for small myocardial necroses at various stages of their development was found in 12 dogs. Recurrent transient myocardial ischemias were shown to be able to lead to myocardial necroses that are not always followed by a typical course of acute myocardial infarction.

[Dynamics of changes in the functional activity of blood polymorphonuclear leukocytes in reversible myocardial ischemia in dogs]. / Dinamika izmeneniia funktsional'noi aktivnosti polimorfnoiadernykh leikotsitov krovi pri obratimoi ishemii miokarda u sobak.

Changes in peripheral blood polymorphonuclear leukocytes (PNL) functional activity in dogs during pre- and post-ischemic periods was investigated using the model of dogs venous circulation reversible disturbances in the chronic experiment and luminol-dependent chemiluminescence method. It was demonstrated that single transitory myocardial ischemia (MI) (5 min.) causes positive increase in PNLs functional activity by the 12th-14th hour of post-ischemic period. Repeated short-term MI (5 min.) was accompanied by the increase in phagocytes activity occurring 6-8 hours following the beginning of post-ischemic period, i.e. two times faster than in the case of primary ischemia. The results obtained allow the conclusion that the accumulative effect of multiple MI and the increase in PNLs functional activity as one of the reasons of cardiomyocytes injury in ischemic region cause pronounced inflammatory and necrotic myocardial changes.

[New hematological method for detecting long-term consequences of short-term myocardial ischemia]. / Novyi gematologicheskii sposob vyiavleniia otdalennykh posledstvii kratkovremennoi ishemii miokarda.

It has been shown in chronic experiments on dogs with reversible disorders of the coronary circulation that the sequels of a 3-5-minute reversible myocardial ischemia might be identified throughout 24-120 hours by an original method suggested by the authors. The method is based on the diagnosis of latent postischemic leukocytosis and other associated hematological shifts.